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Well-differentiated liposarcoma

3 associated genes
4 signs/symptoms

PROTEIN INTERACTIONS: 1

Familial leiomyomatosis

1 OMIM reference -
1 associated gene
10 signs/symptoms

Well-differentiated liposarcoma

Familial leiomyomatosis

CDK4	(UniProt - OMIM)		FH	(UniProt - OMIM)
HMGA2	(UniProt - OMIM)
MDM2	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MDM2	(0.63)	FH

Citations in the biomedical literature:

Well-differentiated liposarcoma		Familial leiomyomatosis
	Synonym(s): - ALT - Atypical lipoma - Atypical lipomatous tumor - WDLS		Synonym(s): - Familial leiomyomatosis with renal carcinoma - Familial leiomyomatosis with renal cell cancer - Familial multiple cutaneous leiomyomas - HLRCC - Hereditary leiomyomatosis - Hereditary leiomyomatosis with renal carcinoma - Hereditary leiomyomatosis with renal cell cancer - Hereditary multiple cutaneous leiomyomas - Multiple cutaneous and uterine leiomyomas

	Classification (Orphanet): - Rare oncologic disease		Classification (Orphanet): - Rare genetic disease - Rare oncologic disease - Rare renal disease - Rare skin disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: unknown Average age onset: adulthood Average age of death: adult Type of inheritance: sporadic		Epidemiological data: Class of prevalence: unknown Average age onset: adolescence / young Average age of death: normal Type of inheritance: autosomal dominant

	External references: No OMIM references No MeSH references		External references: 1 OMIM reference - No MeSH references

Well-differentiated liposarcoma		Familial leiomyomatosis
	Very frequent - Soft tissue sarcoma / cancer / tumor / liposarcoma / myosarcoma - Subcutaneous nodules / lipomas / tumefaction / swelling Occasional - Functional anomalies of the kidney and the urinary tract - Intestinal transit disorder		Very frequent - Autosomal dominant inheritance - Muscle anomalies - Skin tumors / lumps / epidermal cysts Frequent - Pruritus / itching Occasional - Cataract / lens opacification - Esophageal neoplasm / tumor / carcinoma / cancer - Kidney / renal neoplasm / tumor / carcinoma / cancer - Megaesophagus / cardiospasm / congenital dilation of the esophagus / achalasia - Uterus / uterine / cervix / endometrium neoplasm / tumor / carcinoma / cancer - Vaginal / vulvar neoplasm / tumor / carcinoma / cancer